Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM88839
Substrate
n/a
Meas. Tech.
Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay
IC50
7220±941 nM
Citation
 PubChem, PC Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain
Type:
Enzyme
Mol. Mass.:
70502.73
Organism:
Bos taurus (Bovine)
Description:
P00735
Residue:
625
Sequence:
MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
  
Inhibitor
Name:
BDBM88839
Synonyms:
(4Z)-4-[(2-methyl-1H-indol-3-yl)methylene]-2-phenyl-2-oxazolin-5-one | (4Z)-4-[(2-methyl-1H-indol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5-one | (4Z)-4-[(2-methyl-1H-indol-3-yl)methylidene]-2-phenyl-5-oxazolone | MLS000536012 | SMR000155333 | cid_5397501
Type:
Small organic molecule
Emp. Form.:
C19H14N2O2
Mol. Mass.:
302.3267
SMILES:
Cc1[nH]c2ccccc2c1\C=C1/N=C(OC1=O)c1ccccc1 |c:14|
Structure:
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