Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM88861
Substrate
n/a
Meas. Tech.
Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay
IC50
10700±6370 nM
Citation
 PubChem, PC Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain
Type:
Enzyme
Mol. Mass.:
70502.73
Organism:
Bos taurus (Bovine)
Description:
P00735
Residue:
625
Sequence:
MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
  
Inhibitor
Name:
BDBM88861
Synonyms:
MLS000585465 | N'-[(1E)-(2-hydroxy-5-nitrophenyl)methylene]-2-phenylquinoline-4-carbohydrazide | N'-[(E)-(3-nitro-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]-2-phenyl-quinoline-4-carbohydrazide | N'-[(E)-(3-nitro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-2-phenyl-4-quinolinecarbohydrazide | N'-[(E)-(3-nitro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-2-phenylquinoline-4-carbohydrazide | N'-[(E)-(6-keto-3-nitro-cyclohexa-2,4-dien-1-ylidene)methyl]-2-phenyl-cinchoninohydrazide | SMR000207447 | cid_12004565
Type:
Small organic molecule
Emp. Form.:
C23H16N4O4
Mol. Mass.:
412.3975
SMILES:
[O-][N+](=O)c1ccc(=O)[c-](\C=[NH+]\NC(=O)c2cc(nc3ccccc23)-c2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: