Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 5
Ligand
BDBM88739
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay
IC50
7950±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay PubChem Bioassay (2012)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 5
Synonyms:
PTN5_HUMAN | PTPN5 | Tyrosine-protein phosphatase non-receptor type 5 | Tyrosine-protein phosphatase non-receptor type 5 isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
63510.68
Organism:
Homo sapiens (Human)
Description:
gi_90652859
Residue:
565
Sequence:
MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLVSSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSPE
  
Inhibitor
Name:
BDBM88739
Synonyms:
MLS000704210 | N'-[(5-bromo-2-thienyl)methylene]-3-nitrobenzohydrazide | N-[(E)-(5-bromanylthiophen-2-yl)methylideneamino]-3-nitro-benzamide | N-[(E)-(5-bromo-2-thienyl)methyleneamino]-3-nitro-benzamide | N-[(E)-(5-bromo-2-thiophenyl)methylideneamino]-3-nitrobenzamide | N-[(E)-(5-bromothiophen-2-yl)methylideneamino]-3-nitrobenzamide | SMR000227120 | cid_6872971
Type:
Small organic molecule
Emp. Form.:
C12H8BrN3O3S
Mol. Mass.:
354.179
SMILES:
[O-][N+](=O)c1cccc(c1)C(=O)N\N=C\c1ccc(Br)s1
Structure:
Search PDB for entries with ligand similarity: