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Target
Dual specificity protein phosphatase 3
Ligand
BDBM88723
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
719±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88723
Synonyms:
(4-benzylpiperazin-1-yl)-(4-bromophenyl)methanethione | (4-benzylpiperazino)-(4-bromophenyl)methanethione | (4-bromophenyl)-[4-(phenylmethyl)-1-piperazinyl]methanethione | (4-bromophenyl)-[4-(phenylmethyl)piperazin-1-yl]methanethione | 1-benzyl-4-[(4-bromophenyl)carbonothioyl]piperazine | MLS000576820 | SMR000198100 | cid_2185493
Type:
Small organic molecule
Emp. Form.:
C18H19BrN2S
Mol. Mass.:
375.326
SMILES:
Brc1ccc(cc1)C(=S)N1CCN(Cc2ccccc2)CC1
Structure:
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