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Target
Dual specificity protein phosphatase 3
Ligand
BDBM82761
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
2290±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM82761
Synonyms:
2,3-Dihydro-benzo[1,4]dioxine-6-carboxylic acid [1-(4-chloro-3-nitro-phenyl)-meth-(E)-ylidene]-hydrazide | MLS000587937 | N-[(4-chloranyl-3-nitro-phenyl)methylideneamino]-2,3-dihydro-1,4-benzodioxine-6-carboxamide | N-[(4-chloro-3-nitro-benzylidene)amino]-2,3-dihydro-1,4-benzodioxin-6-carboxamide | N-[(4-chloro-3-nitrophenyl)methylideneamino]-2,3-dihydro-1,4-benzodioxin-6-carboxamide | N-[(4-chloro-3-nitrophenyl)methylideneamino]-2,3-dihydro-1,4-benzodioxine-6-carboxamide | N-[(E)-(4-chloro-3-nitro-benzylidene)amino]-2,3-dihydro-1,4-benzodioxin-6-carboxamide | SMR000211981 | cid_3707986
Type:
Small organic molecule
Emp. Form.:
C16H12ClN3O5
Mol. Mass.:
361.737
SMILES:
[O-][N+](=O)c1cc(\C=N\NC(=O)c2ccc3OCCOc3c2)ccc1Cl
Structure:
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