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Target
Dual specificity protein phosphatase 3
Ligand
BDBM57771
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
3520±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM57771
Synonyms:
6-(1-adamantyl)-4-(1,3-benzodioxol-5-yl)-3,4-dihydro-1H-pyrimidine-2-thione | 6-(1-adamantyl)-4-(1,3-benzodioxol-5-yl)-3,4-dihydro-2(1H)-pyrimidinethione | MLS000672341 | SMR000295775 | cid_2969750
Type:
Small organic molecule
Emp. Form.:
C21H24N2O2S
Mol. Mass.:
368.492
SMILES:
[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)C1=NC(=S)NC(C1)c1ccc2OCOc2c1 |t:16,TLB:8:1:12:6.9.5,THB:2:1:9:3.12.5,2:3:9:1.11.8|
Structure:
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