Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM88779
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
38400±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88779
Synonyms:
4-[3-[[4-(2,2-dimethylpropanoylamino)benzoyl]amino]phenoxy]phthalic acid | 4-[3-[[4-(2,2-dimethylpropanoylamino)phenyl]carbonylamino]phenoxy]phthalic acid | 4-[3-[[4-(pivaloylamino)benzoyl]amino]phenoxy]phthalic acid | 4-[3-[[[4-[(2,2-dimethyl-1-oxopropyl)amino]phenyl]-oxomethyl]amino]phenoxy]phthalic acid | MLS001181252 | SMR000502445 | cid_1381903
Type:
Small organic molecule
Emp. Form.:
C26H24N2O7
Mol. Mass.:
476.478
SMILES:
CC(C)(C)C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Oc2ccc(C(O)=O)c(c2)C(O)=O)c1
Structure:
Search PDB for entries with ligand similarity: