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Target
Dual specificity protein phosphatase 3
Ligand
BDBM61325
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
509±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM61325
Synonyms:
1-N,3-N-bis(2-hydroxy-5-nitrophenyl)benzene-1,3-dicarboxamide | MLS001008494 | N,N'-bis(2-hydroxy-5-nitrophenyl)isophthalamide | N,N'-bis(2-hydroxy-5-nitro-phenyl)isophthalamide | N1,N3-bis(2-hydroxy-5-nitrophenyl)benzene-1,3-dicarboxamide | N1,N3-bis(5-nitro-2-oxidanyl-phenyl)benzene-1,3-dicarboxamide | SMR000495849 | cid_3823676
Type:
Small organic molecule
Emp. Form.:
C20H14N4O8
Mol. Mass.:
438.3472
SMILES:
Oc1ccc(cc1NC(=O)c1cccc(c1)C(=O)Nc1cc(ccc1O)[N+]([O-])=O)[N+]([O-])=O
Structure:
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