Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM88789
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
26900±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88789
Synonyms:
6-chloranyl-3-(4-methylphenyl)sulfonyl-1H-quinolin-4-one | 6-chloro-3-(4-methylphenyl)sulfonyl-1H-quinolin-4-one | 6-chloro-3-[(4-methylphenyl)sulfonyl]quinolin-4(1H)-one | 6-chloro-3-tosyl-4-quinolone | MLS001199334 | SMR000562945 | cid_20868646
Type:
Small organic molecule
Emp. Form.:
C16H12ClNO3S
Mol. Mass.:
333.789
SMILES:
Cc1ccc(cc1)S(=O)(=O)c1cnc2ccc(Cl)cc2c1O
Structure:
Search PDB for entries with ligand similarity: