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Target
Dual specificity protein phosphatase 3
Ligand
BDBM83199
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
544±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM83199
Synonyms:
2-[7-(dihydroxymethylene)-5,6-diketo-cyclohepta-1,3-dien-1-yl]acetic acid | 2-[7-(dihydroxymethylidene)-5,6-dioxo-1-cyclohepta-1,3-dienyl]acetic acid | 2-[7-(dihydroxymethylidene)-5,6-dioxocyclohepta-1,3-dien-1-yl]acetic acid | 2-[7-[bis(oxidanyl)methylidene]-5,6-bis(oxidanylidene)cyclohepta-1,3-dien-1-yl]ethanoic acid | 7-(carboxymethyl)-2-hydroxy-3-keto-cyclohepta-1,4,6-triene-1-carboxylic acid | MLS002703575 | SMR001570292 | cid_5380595
Type:
Small organic molecule
Emp. Form.:
C10H8O6
Mol. Mass.:
224.1669
SMILES:
OC(=O)Cc1cccc(=O)c(O)c1C(O)=O
Structure:
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