Target
Dual specificity protein phosphatase 3
Ligand
BDBM88810
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
1270±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88810
Synonyms:
(3E)-5-hydroxy-6-methyl-3-(2,3,5-trihydroxy-4-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)cyclohex-5-ene-1,2,4-trione | (3E)-5-hydroxy-6-methyl-3-(2,3,5-trihydroxy-4-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)cyclohex-5-ene-1,2,4-trione | (3E)-5-hydroxy-6-methyl-3-(2,3,5-trihydroxy-6-keto-4-methyl-cyclohexa-2,4-dien-1-ylidene)cyclohex-5-ene-1,2,4-trione | (3E)-6-methyl-3-[4-methyl-2,3,5-tris(oxidanyl)-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene]-5-oxidanyl-cyclohex-5-ene-1,2,4-trione | MLS002694850 | Oosporein | SMR000470848 | cid_5367836
Type:
Small organic molecule
Emp. Form.:
C14H10O8
Mol. Mass.:
306.2244
SMILES:
CC1C(=O)C(=O)C(C(=O)C1=O)=c1c(O)c(O)c(=C)c(O)c1O |(6.57,5.39,;6.57,3.85,;7.91,3.08,;9.24,3.85,;7.91,1.54,;9.24,.77,;6.57,.77,;5.24,1.54,;3.91,.77,;5.24,3.08,;3.91,3.85,;6.57,-.77,;5.24,-1.54,;3.91,-.77,;5.24,-3.08,;3.91,-3.85,;6.57,-3.85,;6.57,-5.39,;7.91,-3.08,;9.24,-3.85,;7.91,-1.54,;9.24,-.77,)|
Structure:
Search PDB for entries with ligand similarity: