Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89049
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
>99000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89049
Synonyms:
4-(trifluoromethyl)benzoic acid [(Z)-[amino-(2,4-dimethoxyphenyl)methylene]amino] ester | 4-(trifluoromethyl)benzoic acid [(Z)-[amino-(2,4-dimethoxyphenyl)methylidene]amino] ester | MLS-0454719.0001 | [(Z)-[amino-(2,4-dimethoxyphenyl)methylidene]amino] 4-(trifluoromethyl)benzoate | [(Z)-[azanyl-(2,4-dimethoxyphenyl)methylidene]amino] 4-(trifluoromethyl)benzoate | cid_17558163
Type:
Small organic molecule
Emp. Form.:
C17H15F3N2O4
Mol. Mass.:
368.3072
SMILES:
COc1ccc(C(N)=NOC(=O)c2ccc(cc2)C(F)(F)F)c(OC)c1 |w:8.8|
Structure:
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