Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89051
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
1570±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89051
Synonyms:
3-ethoxy-2-naphthalenecarboxylic acid [(Z)-[amino-(4-chlorophenyl)methylidene]amino] ester | 3-ethoxynaphthalene-2-carboxylic acid [(Z)-[amino-(4-chlorophenyl)methylene]amino] ester | MLS-0454721.0001 | [(Z)-[amino-(4-chlorophenyl)methylidene]amino] 3-ethoxynaphthalene-2-carboxylate | [(Z)-[azanyl-(4-chlorophenyl)methylidene]amino] 3-ethoxynaphthalene-2-carboxylate | cid_17558152
Type:
Small organic molecule
Emp. Form.:
C20H17ClN2O3
Mol. Mass.:
368.814
SMILES:
CCOc1cc2ccccc2cc1C(=O)ON=C(N)c1ccc(Cl)cc1 |w:16.17|
Structure:
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