Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89062
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
>99000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89062
Synonyms:
4-chlorobenzoic acid [(Z)-[amino-[4-(4-thiadiazolyl)phenyl]methylidene]amino] ester | 4-chlorobenzoic acid [(Z)-[amino-[4-(thiadiazol-4-yl)phenyl]methylene]amino] ester | MLS-0454731.0001 | [(Z)-[amino-[4-(thiadiazol-4-yl)phenyl]methylidene]amino] 4-chlorobenzoate | [(Z)-[azanyl-[4-(1,2,3-thiadiazol-4-yl)phenyl]methylidene]amino] 4-chloranylbenzoate | cid_9580457
Type:
Small organic molecule
Emp. Form.:
C16H11ClN4O2S
Mol. Mass.:
358.802
SMILES:
NC(=NOC(=O)c1ccc(Cl)cc1)c1ccc(cc1)-c1csnn1 |w:2.2|
Structure:
Search PDB for entries with ligand similarity: