Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89064
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
>99000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89064
Synonyms:
4-chlorobenzoic acid [(Z)-[amino(2,1,3-benzoxadiazol-5-yl)methylidene]amino] ester | 4-chlorobenzoic acid [(Z)-[amino(benzofurazan-5-yl)methylene]amino] ester | MLS-0454733.0001 | [(Z)-[amino(2,1,3-benzoxadiazol-5-yl)methylidene]amino] 4-chlorobenzoate | [(Z)-[azanyl(2,1,3-benzoxadiazol-5-yl)methylidene]amino] 4-chloranylbenzoate | cid_5865054
Type:
Small organic molecule
Emp. Form.:
C14H9ClN4O3
Mol. Mass.:
316.699
SMILES:
N\C(=N/OC(=O)c1ccc(Cl)cc1)c1ccc2nonc2c1
Structure:
Search PDB for entries with ligand similarity: