Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89067
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
33220±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89067
Synonyms:
4-chlorobenzoic acid [(Z)-[amino-(3-cyclopentyloxy-4-methoxyphenyl)methylidene]amino] ester | 4-chlorobenzoic acid [(Z)-[amino-[3-(cyclopentoxy)-4-methoxy-phenyl]methylene]amino] ester | MLS-0454736.0001 | [(Z)-[amino-(3-cyclopentyloxy-4-methoxyphenyl)methylidene]amino] 4-chlorobenzoate | [(Z)-[azanyl-(3-cyclopentyloxy-4-methoxy-phenyl)methylidene]amino] 4-chloranylbenzoate | cid_9584546
Type:
Small organic molecule
Emp. Form.:
C20H21ClN2O4
Mol. Mass.:
388.845
SMILES:
COc1ccc(cc1OC1CCCC1)C(=N)NOC(=O)c1ccc(Cl)cc1
Structure:
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