Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89073
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
69060±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89073
Synonyms:
2-chlorobenzoic acid [(Z)-[amino-[4-(methanesulfonamido)phenyl]methylene]amino] ester | 2-chlorobenzoic acid [(Z)-[amino-[4-(methanesulfonamido)phenyl]methylidene]amino] ester | MLS-0454742.0001 | [(Z)-[amino-[4-(methanesulfonamido)phenyl]methylidene]amino] 2-chlorobenzoate | [(Z)-[azanyl-[4-(methylsulfonylamino)phenyl]methylidene]amino] 2-chloranylbenzoate | cid_9581104
Type:
Small organic molecule
Emp. Form.:
C15H14ClN3O4S
Mol. Mass.:
367.807
SMILES:
CS(=O)(=O)Nc1ccc(cc1)C(N)=NOC(=O)c1ccccc1Cl |w:13.14|
Structure:
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