Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89087
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
48030±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89087
Synonyms:
MLS-0463358.0001 | N-(3-chloranyl-4-fluoranyl-phenyl)-3,7-dimethyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide | N-(3-chloro-4-fluoro-phenyl)-5-keto-3,7-dimethyl-thiazolo[3,2-a]pyrimidine-6-sulfonamide | N-(3-chloro-4-fluorophenyl)-3,7-dimethyl-5-oxo-6-thiazolo[3,2-a]pyrimidinesulfonamide | N-(3-chloro-4-fluorophenyl)-3,7-dimethyl-5-oxo-[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide | cid_22432776
Type:
Small organic molecule
Emp. Form.:
C14H11ClFN3O3S2
Mol. Mass.:
387.837
SMILES:
Cc1csc2nc(C)c(c(=O)n12)S(=O)(=O)Nc1ccc(F)c(Cl)c1
Structure:
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