Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89102
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
91900±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89102
Synonyms:
1-mesyl-N-(6-methyl-1,3-benzothiazol-2-yl)pyrrolidine-2-carboxamide | MLS-0463370.0001 | N-(6-methyl-1,3-benzothiazol-2-yl)-1-methylsulfonyl-2-pyrrolidinecarboxamide | N-(6-methyl-1,3-benzothiazol-2-yl)-1-methylsulfonyl-pyrrolidine-2-carboxamide | N-(6-methyl-1,3-benzothiazol-2-yl)-1-methylsulfonylpyrrolidine-2-carboxamide | cid_18093477
Type:
Small organic molecule
Emp. Form.:
C14H17N3O3S2
Mol. Mass.:
339.433
SMILES:
Cc1ccc2nc(NC(=O)C3CCCN3S(C)(=O)=O)sc2c1
Structure:
Search PDB for entries with ligand similarity: