Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM39541
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
882±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM39541
Synonyms:
MLS000041618 | N-[2-(5-bromanylfuran-2-yl)-3H-benzimidazol-5-yl]thiophene-2-carboxamide | N-[2-(5-bromo-2-furanyl)-3H-benzimidazol-5-yl]-2-thiophenecarboxamide | N-[2-(5-bromo-2-furyl)-3H-benzimidazol-5-yl]thiophene-2-carboxamide | N-[2-(5-bromofuran-2-yl)-3H-benzimidazol-5-yl]thiophene-2-carboxamide | SMR000046012 | cid_664956
Type:
Small organic molecule
Emp. Form.:
C16H10BrN3O2S
Mol. Mass.:
388.239
SMILES:
Brc1ccc(o1)-c1nc2ccc(NC(=O)c3cccs3)cc2[nH]1
Structure:
Search PDB for entries with ligand similarity: