Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM41029
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
18100±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM41029
Synonyms:
1-adamantyl-(3-amino-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridin-2-yl)methanone | 1-adamantyl-(3-azanyl-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridin-2-yl)methanone | Adamantan-1-yl-(3-amino-6-methyl-5,6,7,8-tetrahydro-thieno[2,3-b][1,6]naphthyridin-2-yl)-methanone | MLS000552631 | SMR000146146 | cid_3738927
Type:
Small organic molecule
Emp. Form.:
C22H27N3OS
Mol. Mass.:
381.534
SMILES:
[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)C(=O)c1sc2nc3CCN(C)Cc3cc2c1N |TLB:8:1:12:6.9.5,8:6:12:1.11.2,THB:5:6:11:3.12.2|
Structure:
Search PDB for entries with ligand similarity: