Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM77672
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
17300±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM77672
Synonyms:
MLS000102881 | N-(4-tert-butyl-1,3-thiazol-2-yl)-5-chloranyl-thiophene-2-carboxamide | N-(4-tert-butyl-1,3-thiazol-2-yl)-5-chlorothiophene-2-carboxamide | N-(4-tert-butyl-2-thiazolyl)-5-chloro-2-thiophenecarboxamide | N-(4-tert-butylthiazol-2-yl)-5-chloro-thiophene-2-carboxamide | SMR000017402 | cid_1247280
Type:
Small organic molecule
Emp. Form.:
C12H13ClN2OS2
Mol. Mass.:
300.827
SMILES:
CC(C)(C)c1csc(NC(=O)c2ccc(Cl)s2)n1
Structure:
Search PDB for entries with ligand similarity: