Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM77785
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
1750±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM77785
Synonyms:
2-chloranyl-N-[3-(4-methylphenyl)-1-phenyl-pyrazol-4-yl]ethanamide | 2-chloro-N-[1-phenyl-3-(p-tolyl)pyrazol-4-yl]acetamide | 2-chloro-N-[3-(4-methylphenyl)-1-phenyl-4-pyrazolyl]acetamide | 2-chloro-N-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]acetamide | MLS000770839 | SMR000344083 | cid_2104090
Type:
Small organic molecule
Emp. Form.:
C18H16ClN3O
Mol. Mass.:
325.792
SMILES:
Cc1ccc(cc1)-c1nn(cc1NC(=O)CCl)-c1ccccc1
Structure:
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