Reaction Details Report a problem with these data
Target
High affinity choline transporter 1
Ligand
BDBM89158
Substrate
n/a
Meas. Tech.
Dose responses of compounds that activate the Choline Transporter (CHT) - 10 point CRC
EC50
12930±n/a nM
Citation
 PubChem, PC Dose responses of compounds that activate the Choline Transporter (CHT) - 10 point CRC PubChem Bioassay (2012)[AID] 
Target
Name:
High affinity choline transporter 1
Synonyms:
CHT1 | High-affinity choline transporter | SC5A7_HUMAN | SLC5A7 | high affinity choline transporter 1
Type:
PROTEIN
Mol. Mass.:
63194.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1464247
Residue:
580
Sequence:
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
  
Inhibitor
Name:
BDBM89158
Synonyms:
4-cyano-2-fluoranyl-N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]benzamide | 4-cyano-2-fluoro-N-[2-(4-isobutyrylpiperazino)phenyl]benzamide | 4-cyano-2-fluoro-N-[2-[4-(2-methyl-1-oxopropyl)-1-piperazinyl]phenyl]benzamide | 4-cyano-2-fluoro-N-[2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]benzamide | MLS000708271 | SMR000287738 | cid_1091621
Type:
Small organic molecule
Emp. Form.:
C22H23FN4O2
Mol. Mass.:
394.442
SMILES:
CC(C)C(=O)N1CCN(CC1)c1ccccc1NC(=O)c1ccc(cc1F)C#N
Structure:
Search PDB for entries with ligand similarity: