Reaction Details Report a problem with these data
Target
High affinity choline transporter 1
Ligand
BDBM89176
Substrate
n/a
Meas. Tech.
Dose responses of compounds that activate the Choline Transporter (CHT) - 10 point CRC
EC50
21340±n/a nM
Citation
 PubChem, PC Dose responses of compounds that activate the Choline Transporter (CHT) - 10 point CRC PubChem Bioassay (2012)[AID] 
Target
Name:
High affinity choline transporter 1
Synonyms:
CHT1 | High-affinity choline transporter | SC5A7_HUMAN | SLC5A7 | high affinity choline transporter 1
Type:
PROTEIN
Mol. Mass.:
63194.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1464247
Residue:
580
Sequence:
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
  
Inhibitor
Name:
BDBM89176
Synonyms:
MLS001138582 | N-(6-amino-1-butyl-2,4-diketo-pyrimidin-5-yl)-1-(4-chlorobenzoyl)-N-isoamyl-nipecotamide | N-(6-amino-1-butyl-2,4-dioxo-5-pyrimidinyl)-1-[(4-chlorophenyl)-oxomethyl]-N-(3-methylbutyl)-3-piperidinecarboxamide | N-(6-amino-1-butyl-2,4-dioxopyrimidin-5-yl)-1-(4-chlorobenzoyl)-N-(3-methylbutyl)piperidine-3-carboxamide | N-[6-azanyl-1-butyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-1-(4-chlorophenyl)carbonyl-N-(3-methylbutyl)piperidine-3-carboxamide | SMR000712523 | cid_24980168
Type:
Small organic molecule
Emp. Form.:
C26H36ClN5O4
Mol. Mass.:
518.048
SMILES:
CCCCn1c(N)c(N(CCC(C)C)C(=O)C2CCCN(C2)C(=O)c2ccc(Cl)cc2)c(=O)[nH]c1=O
Structure:
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