Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM72465
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
75220±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM72465
Synonyms:
7-(2-furanylmethyl)-3-[3-(4-morpholinyl)propyl]-5,6-diphenyl-4-pyrrolo[2,3-d]pyrimidinimine | 7-(2-furylmethyl)-3-[3-(4-morpholinyl)propyl]-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-imine | 7-(furan-2-ylmethyl)-3-(3-morpholin-4-ylpropyl)-5,6-diphenyl-pyrrolo[2,3-d]pyrimidin-4-imine | 7-(furan-2-ylmethyl)-3-(3-morpholin-4-ylpropyl)-5,6-diphenylpyrrolo[2,3-d]pyrimidin-4-imine | MLS000672508 | SMR000296129 | [7-(2-furfuryl)-3-(3-morpholinopropyl)-5,6-diphenyl-pyrrolo[2,3-d]pyrimidin-4-ylidene]amine | cid_2973487
Type:
Small organic molecule
Emp. Form.:
C30H31N5O2
Mol. Mass.:
493.5994
SMILES:
N=c1n(CCCN2CCOCC2)cnc2n(Cc3ccco3)c(c(-c3ccccc3)c12)-c1ccccc1
Structure:
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