Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89085
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
79200±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89085
Synonyms:
MLS-0463356.0001 | N-[2-chloranyl-5-(trifluoromethyl)phenyl]-3,7-dimethyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide | N-[2-chloro-5-(trifluoromethyl)phenyl]-3,7-dimethyl-5-oxo-6-thiazolo[3,2-a]pyrimidinesulfonamide | N-[2-chloro-5-(trifluoromethyl)phenyl]-3,7-dimethyl-5-oxo-[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide | N-[2-chloro-5-(trifluoromethyl)phenyl]-5-keto-3,7-dimethyl-thiazolo[3,2-a]pyrimidine-6-sulfonamide | cid_20098613
Type:
Small organic molecule
Emp. Form.:
C15H11ClF3N3O3S2
Mol. Mass.:
437.844
SMILES:
Cc1csc2nc(C)c(c(=O)n12)S(=O)(=O)Nc1cc(ccc1Cl)C(F)(F)F
Structure:
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