Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89091
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
>99000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89091
Synonyms:
3,7-dimethyl-5-oxidanylidene-N-[4-(piperidin-1-ylmethyl)phenyl]-[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide | 3,7-dimethyl-5-oxo-N-[4-(1-piperidinylmethyl)phenyl]-6-thiazolo[3,2-a]pyrimidinesulfonamide | 3,7-dimethyl-5-oxo-N-[4-(piperidin-1-ylmethyl)phenyl]-[1,3]thiazolo[3,2-a]pyrimidine-6-sulfonamide | 5-keto-3,7-dimethyl-N-[4-(piperidinomethyl)phenyl]thiazolo[3,2-a]pyrimidine-6-sulfonamide | MLS-0463359.0001 | cid_20098622
Type:
Small organic molecule
Emp. Form.:
C20H24N4O3S2
Mol. Mass.:
432.56
SMILES:
Cc1csc2nc(C)c(c(=O)n12)S(=O)(=O)Nc1ccc(CN2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: