Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89096
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
48500±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89096
Synonyms:
8-(2-furanylmethyl)-9,10-dimethyl-3,4-dihydropyrrolo[1,2]pyrimido[3,5-b][1,2,4]thiadiazine 2,2-dioxide | 8-(2-furfuryl)-9,10-dimethyl-3,4-dihydropyrrolo[1,2]pyrimido[3,5-b][1,2,4]thiadiazine 2,2-dioxide | 8-(furan-2-ylmethyl)-9,10-dimethyl-3,4-dihydropyrrolo[1,2]pyrimido[3,5-b][1,2,4]thiadiazine 2,2-dioxide | MLS-0463364.0001 | cid_8891617
Type:
Small organic molecule
Emp. Form.:
C15H16N4O3S
Mol. Mass.:
332.378
SMILES:
Cc1c(C)n(Cc2ccco2)c2N=CN3C=CS(=O)(=O)NC3c12 |c:13,16|
Structure:
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