Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89136
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
9480±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89136
Synonyms:
MLS-0299362.0001 | N-[(E)-[(E)-2-chloranyl-3-phenyl-prop-2-enylidene]amino]thiophene-2-carboxamide | N-[(E)-[(E)-2-chloro-3-phenyl-prop-2-enylidene]amino]thiophene-2-carboxamide | N-[(E)-[(E)-2-chloro-3-phenylprop-2-enylidene]amino]-2-thiophenecarboxamide | N-[(E)-[(E)-2-chloro-3-phenylprop-2-enylidene]amino]thiophene-2-carboxamide | cid_6861718
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2OS
Mol. Mass.:
290.768
SMILES:
Cl\C(\C=N\NC(=O)c1cccs1)=C\c1ccccc1
Structure:
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