Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM26682
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
4520±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM26682
Synonyms:
2-amino-6-(4-hydroxyphenyl)-4-phenylpyridine-3-carbonitrile | 2-amino-6-(4-ketocyclohexa-2,5-dien-1-ylidene)-4-phenyl-1H-pyridine-3-carbonitrile | 2-aminopyridine-3-carbonitrile, 10
Type:
Small organic molecule
Emp. Form.:
C18H13N3O
Mol. Mass.:
287.3153
SMILES:
Nc1nc(cc(-c2ccccc2)c1C#N)-c1ccc(O)cc1
Structure:
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