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Target
Caspase-9
Ligand
BDBM89493
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay - Set 2
EC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay - Set 2 PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM89493
Synonyms:
(3E)-3-(6-ketocyclohexa-2,4-dien-1-ylidene)isoxazolidine-5-carboxylic acid | (3E)-3-(6-oxidanylidenecyclohexa-2,4-dien-1-ylidene)-1,2-oxazolidine-5-carboxylic acid | (3E)-3-(6-oxo-1-cyclohexa-2,4-dienylidene)-5-isoxazolidinecarboxylic acid | (3E)-3-(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2-oxazolidine-5-carboxylic acid | MLS-0466808.0001 | cid_25220802
Type:
Small organic molecule
Emp. Form.:
C10H9NO4
Mol. Mass.:
207.1828
SMILES:
OC(=O)C1CC(=NO1)c1ccccc1O |c:5|
Structure:
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