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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM44588
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM44588
Synonyms:
2-cyano-2-[3-(4-o-phenetylpiperazino)quinoxalin-2-yl]acetic acid allyl ester | 2-cyano-2-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]-2-quinoxalinyl]acetic acid prop-2-enyl ester | MLS000036474 | SMR000041596 | cid_660828 | prop-2-enyl 2-cyano-2-[3-[4-(2-ethoxyphenyl)piperazin-1-yl]quinoxalin-2-yl]acetate | prop-2-enyl 2-cyano-2-[3-[4-(2-ethoxyphenyl)piperazin-1-yl]quinoxalin-2-yl]ethanoate
Type:
Small organic molecule
Emp. Form.:
C26H27N5O3
Mol. Mass.:
457.5243
SMILES:
CCOc1ccccc1N1CCN(CC1)c1nc2ccccc2nc1C(C#N)C(=O)OCC=C
Structure:
Search PDB for entries with ligand similarity: