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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89599
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89599
Synonyms:
2-[2-(1,3-benzodioxol-5-ylamino)-2-keto-ethyl]-3-keto-N-phenyl-piperazine-1-carboxamide | 2-[2-(1,3-benzodioxol-5-ylamino)-2-oxidanylidene-ethyl]-3-oxidanylidene-N-phenyl-piperazine-1-carboxamide | 2-[2-(1,3-benzodioxol-5-ylamino)-2-oxoethyl]-3-oxo-N-phenyl-1-piperazinecarboxamide | 2-[2-(1,3-benzodioxol-5-ylamino)-2-oxoethyl]-3-oxo-N-phenylpiperazine-1-carboxamide | MLS000039698 | SMR000037538 | cid_666175
Type:
Small organic molecule
Emp. Form.:
C20H20N4O5
Mol. Mass.:
396.3966
SMILES:
O=C(CC1N(CCNC1=O)C(=O)Nc1ccccc1)Nc1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: