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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89688
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
4850±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89688
Synonyms:
6-[(3,5-dimethylphenyl)sulfamoyl]-N,N-diethyl-4-keto-1H-quinoline-3-carboxamide | 6-[(3,5-dimethylphenyl)sulfamoyl]-N,N-diethyl-4-oxidanylidene-1H-quinoline-3-carboxamide | 6-[(3,5-dimethylphenyl)sulfamoyl]-N,N-diethyl-4-oxo-1H-quinoline-3-carboxamide | 6-{[(3,5-dimethylphenyl)amino]sulfonyl}-N,N-diethyl-4-oxo-1,4-dihydroquinoline-3-carboxamide | MLS000091975 | SMR000026499 | cid_3245541
Type:
Small organic molecule
Emp. Form.:
C22H25N3O4S
Mol. Mass.:
427.517
SMILES:
CCN(CC)C(=O)c1cnc2ccc(cc2c1O)S(=O)(=O)Nc1cc(C)cc(C)c1
Structure:
Search PDB for entries with ligand similarity: