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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89693
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89693
Synonyms:
2,2-difluoro-2-[(2-methyl-1H-indol-3-yl)thio]acetic acid methyl ester | MLS000089932 | SMR000024550 | cid_595568 | methyl 2,2-bis(fluoranyl)-2-[(2-methyl-1H-indol-3-yl)sulfanyl]ethanoate | methyl 2,2-difluoro-2-[(2-methyl-1H-indol-3-yl)sulfanyl]acetate | methyl difluoro[(2-methyl-1H-indol-3-yl)thio]acetate
Type:
Small organic molecule
Emp. Form.:
C12H11F2NO2S
Mol. Mass.:
271.283
SMILES:
COC(=O)C(F)(F)Sc1c(C)[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: