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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89710
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89710
Synonyms:
(4,6-dipiperidino-s-triazin-2-yl)-homoveratryl-amine | MLS000096893 | N-[2-(3,4-dimethoxyphenyl)ethyl]-4,6-bis(1-piperidinyl)-1,3,5-triazin-2-amine | N-[2-(3,4-dimethoxyphenyl)ethyl]-4,6-di(piperidin-1-yl)-1,3,5-triazin-2-amine | N-[2-(3,4-dimethoxyphenyl)ethyl]-4,6-di-1-piperidinyl-1,3,5-triazin-2-amine | SMR000074636 | cid_1303751
Type:
Small organic molecule
Emp. Form.:
C23H34N6O2
Mol. Mass.:
426.5551
SMILES:
COc1ccc(CCNc2nc(nc(n2)N2CCCCC2)N2CCCCC2)cc1OC
Structure:
Search PDB for entries with ligand similarity: