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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89755
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
8370±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89755
Synonyms:
5-amino-1-(2,5-dimethylbenzyl)-N-(3,5-dimethylphenyl)triazole-4-carboxamide | 5-amino-N-(3,5-dimethylphenyl)-1-[(2,5-dimethylphenyl)methyl]-4-triazolecarboxamide | 5-amino-N-(3,5-dimethylphenyl)-1-[(2,5-dimethylphenyl)methyl]triazole-4-carboxamide | 5-azanyl-N-(3,5-dimethylphenyl)-1-[(2,5-dimethylphenyl)methyl]-1,2,3-triazole-4-carboxamide | MLS000117957 | SMR000094905 | cid_5309788
Type:
Small organic molecule
Emp. Form.:
C20H23N5O
Mol. Mass.:
349.4295
SMILES:
Cc1ccc(C)c(Cn2nnc(C(=O)Nc3cc(C)cc(C)c3)c2N)c1
Structure:
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