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Target
ATP-binding cassette sub-family B member 6
Ligand
BDBM71449
Substrate
n/a
Meas. Tech.
Dose Response of Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Cherry Pick01
EC50
74540±n/a nM
Citation
 PubChem, PC Dose Response of Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Cherry Pick01 PubChem Bioassay (2012)[AID] 
Target
Name:
ATP-binding cassette sub-family B member 6
Synonyms:
ABCB6 | ABCB6_HUMAN | ATP-binding cassette sub-family B member 6, mitochondrial | MTABC3 | PRP | UMAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
93896.51
Organism:
Homo sapiens (Human)
Description:
gi_9955963
Residue:
842
Sequence:
MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER
  
Inhibitor
Name:
BDBM71449
Synonyms:
5-chloranyl-N-(2,6-dimethylphenyl)-2-[(3-methylphenyl)methylsulfonyl]pyrimidine-4-carboxamide | 5-chloro-N-(2,6-dimethylphenyl)-2-(3-methylbenzyl)sulfonyl-pyrimidine-4-carboxamide | 5-chloro-N-(2,6-dimethylphenyl)-2-[(3-methylphenyl)methylsulfonyl]-4-pyrimidinecarboxamide | 5-chloro-N-(2,6-dimethylphenyl)-2-[(3-methylphenyl)methylsulfonyl]pyrimidine-4-carboxamide | MLS001116228 | SMR000625797 | cid_16446993
Type:
Small organic molecule
Emp. Form.:
C21H20ClN3O3S
Mol. Mass.:
429.92
SMILES:
Cc1cccc(CS(=O)(=O)c2ncc(Cl)c(n2)C(=O)Nc2c(C)cccc2C)c1
Structure:
Search PDB for entries with ligand similarity: