Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM91527
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2
Temperature
298.15±n/a K
IC50
>99000±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM91527
Synonyms:
3-chloranyl-N-methyl-N-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | 3-chloro-N-methyl-N-(phenylmethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide | MLS-0266407.0001 | N-benzyl-3-chloro-N-methyl-pyrazolo[1,5-a]pyrimidine-2-carboxamide | N-benzyl-3-chloro-N-methylpyrazolo[1,5-a]pyrimidine-2-carboxamide | cid_2243054
Type:
Small organic molecule
Emp. Form.:
C15H13ClN4O
Mol. Mass.:
300.743
SMILES:
CN(Cc1ccccc1)C(=O)c1nn2cccnc2c1Cl
Structure:
