Reaction Details
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Tyrosine-protein phosphatase non-receptor type 5
Ligand
BDBM88765
Substrate
n/a
Meas. Tech.
Dose response orthogonal assay of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a colorimetric intensity assay.
IC50
>80000±n/a nM
Citation
PubChem, PC Dose response orthogonal assay of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a colorimetric intensity assay. PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Tyrosine-protein phosphatase non-receptor type 5
Synonyms:
PTN5_HUMAN | PTPN5 | Tyrosine-protein phosphatase non-receptor type 5 | Tyrosine-protein phosphatase non-receptor type 5 isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
63510.68
Organism:
Homo sapiens (Human)
Description:
gi_90652859
Residue:
565
Sequence:
MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLVSSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSPE
Inhibitor
Name:
BDBM88765
Synonyms:
1-(1-acetyl-4-piperidinyl)-3-(4-methylphenyl)-1-[2-(4-morpholinyl)ethyl]thiourea | 1-(1-acetyl-4-piperidyl)-1-(2-morpholinoethyl)-3-(p-tolyl)thiourea | 1-(1-acetylpiperidin-4-yl)-3-(4-methylphenyl)-1-(2-morpholin-4-ylethyl)thiourea | 1-(1-ethanoylpiperidin-4-yl)-3-(4-methylphenyl)-1-(2-morpholin-4-ylethyl)thiourea | MLS000683626 | N-(1-acetylpiperidin-4-yl)-N'-(4-methylphenyl)-N-(2-morpholin-4-ylethyl)thiourea | SMR000311783 | cid_4062176
Type:
Small organic molecule
Emp. Form.:
C21H32N4O2S
Mol. Mass.:
404.569
SMILES:
CC(=O)N1CCC(CC1)N(CCN1CCOCC1)C(=S)Nc1ccc(C)cc1
Structure:
