Reaction Details Report a problem with these data
Target
Acyl-protein thioesterase 2
Ligand
BDBM92723
Substrate
n/a
Meas. Tech.
Enzymatic Protein Activity Assay
IC50
2.95e+3± 1.5e+2 nM
Citation
 Zimmermann, TJ; Bürger, M; Tashiro, E; Kondoh, Y; Martinez, NE; Görmer, K; Rosin-Steiner, S; Shimizu, T; Ozaki, S; Mikoshiba, K; Watanabe, N; Hall, D; Vetter, IR; Osada, H; Hedberg, C; Waldmann, H Boron-based inhibitors of acyl protein thioesterases 1 and 2. Chembiochem 14:115-22 (2013) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 2
Synonyms:
APT2 | Acyl-protein thioesterase 2 (APT2 WT) | LYPA2_HUMAN | LYPLA2 | Lysophospholipase II
Type:
Protein
Mol. Mass.:
24740.23
Organism:
Homo sapiens (Human)
Description:
O95372
Residue:
231
Sequence:
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
  
Inhibitor
Name:
BDBM92723
Synonyms:
Phenylboronic acid, 16
Type:
Small molecule
Emp. Form.:
C8H8BNO6
Mol. Mass.:
224.963
SMILES:
COC(=O)c1cc(cc(c1)N(=O)=O)B(O)O
Structure:
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