Reaction Details Report a problem with these data
Target
Acyl-protein thioesterase 2
Ligand
BDBM26140
Substrate
n/a
Meas. Tech.
Enzymatic Protein Activity Assay
IC50
1.13e+4± 4.0e+3 nM
Citation
 Zimmermann, TJ; Bürger, M; Tashiro, E; Kondoh, Y; Martinez, NE; Görmer, K; Rosin-Steiner, S; Shimizu, T; Ozaki, S; Mikoshiba, K; Watanabe, N; Hall, D; Vetter, IR; Osada, H; Hedberg, C; Waldmann, H Boron-based inhibitors of acyl protein thioesterases 1 and 2. Chembiochem 14:115-22 (2013) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 2
Synonyms:
APT2 | Acyl-protein thioesterase 2 (APT2 WT) | LYPA2_HUMAN | LYPLA2 | Lysophospholipase II
Type:
Protein
Mol. Mass.:
24740.23
Organism:
Homo sapiens (Human)
Description:
O95372
Residue:
231
Sequence:
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
  
Inhibitor
Name:
BDBM26140
Synonyms:
1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylboronic acid, 19 | CHEMBL143399 | Phenylboronic acid, 21
Type:
Small organic molecule
Emp. Form.:
C8H7BO3
Mol. Mass.:
161.95
SMILES:
OB(O)c1cc2ccccc2o1
Structure:
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