Reaction Details Report a problem with these data
Target
3-dehydroquinate synthase
Ligand
BDBM93205
Substrate
n/a
Meas. Tech.
Enzyme Inhibition
Ki
3.5e+4±n/a nM
Citation
 Widlanski, T; Bender, SL; Knowles, JR Dehydroquinate synthase: the use of substrate analogues to probe the late steps of the catalyzed reaction. Biochemistry 28:7572-82 (1989) [PubMed]  Article 
Target
Name:
3-dehydroquinate synthase
Synonyms:
AROB_ECOLI | aroB
Type:
Enzyme
Mol. Mass.:
38878.02
Organism:
Escherichia coli (strain K12)
Description:
P07639
Residue:
362
Sequence:
MERIVVTLGERSYPITIASGLFNEPASFLPLKSGEQVMLVTNETLAPLYLDKVRGVLEQAGVNVDSVILPDGEQYKSLAVLDTVFTALLQKPHGRDTTLVALGGGVVGDLTGFAAASYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPASVVVDLDCLKTLPPRELASGLAEVIKYGIILDGAFFNWLEENLDALLRLDGPAMAYCIRRCCELKAEVVAADERETGLRALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGMVMAARTSERLGQFSSAETQRIITLLKRAGLPVNGPREMSAQAYLPHMLRDKKVLAGEMRLILPLAIGKSEVRSGVSHELVLNAIADCQSA
  
Inhibitor
Name:
BDBM93205
Synonyms:
4,5-dihydroxy-6-(phosphonatomethyl)oxane-2-carboxylate, 3
Type:
Small molecule
Emp. Form.:
C7H10O8P
Mol. Mass.:
253.1249
SMILES:
OC1CC(OC(CP([O-])([O-])=O)C1O)C([O-])=O
Structure:
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