Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM61011
Substrate
n/a
IC50
1775±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) PubChem Bioassay (2012)[AID] 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM61011
Synonyms:
(3'S,4'R)-1'-(4-chlorophenyl)-2'-cyano-spiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylic acid dimethyl ester | (3'S,4'R)-1'-(4-chlorophenyl)-2'-cyanospiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylic acid dimethyl ester | MLS000549148 | SMR000113936 | cid_9499902 | dimethyl (3'S,4'R)-1'-(4-chlorophenyl)-2'-cyano-spiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylate | dimethyl (3'S,4'R)-1'-(4-chlorophenyl)-2'-cyanospiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylate | dimethyl 1-(4-chlorophenyl)-2-cyanospiro[pyrazolidine-5,9'-(9'H)-fluorene]-3,4-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C26H20ClN3O4
Mol. Mass.:
473.908
SMILES:
COC(=O)[C@@H]1[C@@H](C(=O)OC)C2(N(N1C#N)c1ccc(Cl)cc1)c1ccccc1-c1ccccc21
Structure:
Search PDB for entries with ligand similarity: