Reaction Details Report a problem with these data
Target
Sentrin-specific protease 8
Ligand
BDBM93583
Substrate
n/a
IC50
365±39 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93583
Synonyms:
MLS000701606 | N-[(Z)-[(3E)-3-(carbomethoxyhydrazono)indan-1-ylidene]amino]carbamic acid methyl ester | N-[(Z)-[(3E)-3-(methoxycarbonylhydrazinylidene)-1-indenylidene]amino]carbamic acid methyl ester | SMR000230285 | cid_11842271 | methyl 2-{3-[(methoxycarbonyl)hydrazono]-2,3-dihydro-1H-inden-1-ylidene}hydrazinecarboxylate | methyl N-[(Z)-[(3E)-3-(methoxycarbonylhydrazinylidene)inden-1-ylidene]amino]carbamate
Type:
Small organic molecule
Emp. Form.:
C13H14N4O4
Mol. Mass.:
290.2747
SMILES:
COC(=O)NN=C1CC(=NNC(=O)OC)c2ccccc12 |w:5.4,9.9|
Structure:
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