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Target
Sentrin-specific protease 8
Ligand
BDBM93658
Substrate
n/a
IC50
528±185 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93658
Synonyms:
2-(3-chlorobenzyl)-1,3(2H,4H)-isoquinolinedione | 2-(3-chlorobenzyl)-4H-isoquinoline-1,3-quinone | 2-[(3-chlorophenyl)methyl]-4H-isoquinoline-1,3-dione | MLS001165254 | SMR000549781 | cid_1475564
Type:
Small organic molecule
Emp. Form.:
C16H12ClNO2
Mol. Mass.:
285.725
SMILES:
Clc1cccc(CN2C(=O)Cc3ccccc3C2=O)c1
Structure:
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