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Target
Sentrin-specific protease 8
Ligand
BDBM64790
Substrate
n/a
IC50
284±28 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM64790
Synonyms:
3a,8b-Dihydroxy-2-methyl-4-oxo-4,8b-dihydro-3aH-indeno[1,2-b]furan-3-carboxylic acid ethyl ester | 3a,8b-dihydroxy-2-methyl-4-oxo-3-indeno[1,2-b]furancarboxylic acid ethyl ester | 3a,8b-dihydroxy-4-keto-2-methyl-indeno[1,2-b]furan-3-carboxylic acid ethyl ester | MLS000768248 | SMR000431569 | cid_2828330 | ethyl 2-methyl-3a,8b-bis(oxidanyl)-4-oxidanylidene-indeno[1,2-b]furan-3-carboxylate | ethyl 3a,8b-dihydroxy-2-methyl-4-oxoindeno[1,2-b]furan-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H14O6
Mol. Mass.:
290.2681
SMILES:
CCOC(=O)C1=C(C)OC2(O)c3ccccc3C(=O)C12O |c:5|
Structure:
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