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Target
Sentrin-specific protease 8
Ligand
BDBM83904
Substrate
n/a
IC50
384±43 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM83904
Synonyms:
4-tert-Butyl-benzoic acid N'-(2,6-di-piperidin-1-yl-pyrimidin-4-yl)-hydrazide | 4-tert-butyl-N'-(2,6-dipiperidinopyrimidin-4-yl)benzohydrazide | 4-tert-butyl-N'-[2,6-di(piperidin-1-yl)pyrimidin-4-yl]benzohydrazide | MLS000563386 | N'-[2,6-bis(1-piperidinyl)-4-pyrimidinyl]-4-tert-butylbenzohydrazide | SMR000176235 | cid_3121367
Type:
Small organic molecule
Emp. Form.:
C25H36N6O
Mol. Mass.:
436.5929
SMILES:
CC(C)(C)c1ccc(cc1)C(=O)NNc1cc(nc(n1)N1CCCCC1)N1CCCCC1
Structure:
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