Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM35354
Substrate
n/a
IC50
1430±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM35354
Synonyms:
4-N-(2-methylcyclohexyl)-1-N-(pyridin-4-ylmethyl)benzene-1,4-disulfonamide | Benzene-1,4-disulfonic acid 1-[(2-methyl-cyclohexyl)-amide] 4-[(pyridin-4-ylmethyl)-amide] | MLS000032786 | N'-(2-methylcyclohexyl)-N-(4-pyridylmethyl)benzene-1,4-disulfonamide | N4-(2-methylcyclohexyl)-N1-(pyridin-4-ylmethyl)benzene-1,4-disulfonamide | SMR000007163 | cid_645986
Type:
Small organic molecule
Emp. Form.:
C19H25N3O4S2
Mol. Mass.:
423.549
SMILES:
CC1CCCCC1NS(=O)(=O)c1ccc(cc1)S(=O)(=O)NCc1ccncc1
Structure:
Search PDB for entries with ligand similarity: